Haematology News/Publications

News

Short Term Project

Applications are invited from candidates who are interested in doing short term projects at the Haematology department, CMC, Vellore.

Duration : 4 to 6 Month's
Eligibility : Candidates who are pursuing MSc (Life Sciences/ Biotechnology/B.Tech, M.Tech, MBBS.)

Application process

Applications will considered for the following sessions, every year

Session	Duration of project	Last date to receive application
1	January-June	August 31st of previous year
2	July-December	March 31st of current year

Candidates who are selected for this course will be informed by the 15th of September (Session 1) or April (Session 2), respectively.

Please note: The short term project applications and communications should be sent to the following e-mail ID only : [email protected]

Recent Publications:

• Allogeneic Stem Cell Transplantation forThalassemia Major. Hematol Oncol Clin North Am. 2014 Dec;28(6):1187-1200. doi:10.1016/j.hoc.2014.08.009. Mathews V, Srivastava A, Chandy M. Epub 2014 Sep 22. Review. PubMed PMID: 25459187.
• Effect of cytosine arabinoside metabolizing enzyme expression on drug toxicity in acute myeloid leukemia. Abraham A, Devasia AJ, Varatharajan S, Karathedath S, Balasubramanian P,Mathews V. Ann Hematol. 2014 Nov 13. [Epub ahead of print] PubMed PMID: 25391240.
• Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in ß-thalassemia. Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Ann Hematol. 2014 Dec;93(12):2093-5. doi: 10.1007/s00277-014-2113-1. Epub 2014 May 28. PubMed PMID: 24867648.
• Mathews V. Generic imatinib: the real-deal or just a deal? Leuk Lymphoma. 2014 Dec;55(12):2678-80. doi: 10.3109/10428194.2014.921299. PubMed PMID:24798742.
• Sen D, Balakrishnan B, Jayandharan GR. Cellular unfolded protein response against viruses used in gene therapy. Front Microbiol 2014; in press
• Selot R, Hareendran S, Jayandharan GR. Developing immunologically inert adeno-associated virus (AAV) vectors for gene therapy: possibilities and limitations. Curr Pharm Biotechnol 2014; in press.
• Balakrishnan B, Jayandharan GR. Basic biology of Adeno-associated virus (AAV) vectors used in gene therapy. Curr Gene Ther 2014; in press.
• Ramesh B. Batchu, Oksana V. Gruzdyna, Amberly M. Moreno-Bost, Susann Szmania, Jayandharan GR, Arun Srivastava, Bala K. Kolli, Donald W. Weaver, Frits van Rhee, Scott A. Gruber. Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector. Vaccine 6 January 2014 [Epub ahead of print].
• Hareendran S, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR. Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them. Rev Med Virol. 2013 Sep 10. doi: 10.1002/rmv.1762. [Epub ahead of print] PubMed PMID: 24023004.
• Athiyarath R, Arora N, Fuster F, Schwarzenbacher R, Ahmed R, George B, Chandy M, Srivastava A, Rojas AM, Sanchez M, Edison ES. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Haematol. 2013 Jul 24. doi: 10.1111/bjh.12487. [Epub ahead of print] PubMed PMID: 23888904.
• Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias-expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2013 Jun 22. [Epub ahead of print] PubMed PMID: 23793916.
• Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr;137(4):777-84. PubMed PMID: 23703347; PubMed Central PMCID: PMC3724260.
• Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013;3:1832. doi: 10.1038/srep01832. PubMed PMID: 23665951; PubMed Central PMCID: PMC3652085.
• Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved clinical outcomes of high risk β Thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts. PLoS One. 2013 Apr 26;8(4):e61637. doi: 10.1371/journal.pone.0061637. Print 2013. PubMed PMID: 23637873; PubMed Central PMCID: PMC3637210.
• Sen D, Gadkari RA, Sudha G, Gabriel N, Kumar YS, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC, Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):104-16. doi: 10.1089/hgtb.2012.195. PubMed PMID: 23442071.
• Gabriel N, Hareendran S, Sen D, Gadkari RA, Sudha G, Selot R, Hussain M, Dhaksnamoorthy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):80-93. doi: 10.1089/hgtb.2012.194. Epub 2013 Mar 15. PubMed PMID: 23379478.
• Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, Jayandharan GR. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One. 2013;8(1):e53845. doi: 10.1371/journal.pone.0053845. Epub 2013 Jan 8. PubMed PMID: 23320106; PubMed Central PMCID: PMC3540029.
• Jain PP, Parihar M, Ahmed R, Abraham A, Vishwabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis. Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):347-51. doi: 10.4103/0377-4929.101742. PubMed PMID: 23032829.
• Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86. doi: 10.1007/s00228-012-1291-9. Epub 2012 May 5. PubMed PMID: 22562609.
• Sabapathy V, Ravi S, Srivastava V, Srivastava A, Kumar S. Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity. Stem Cells Int. 2012;2012:174328. doi: 10.1155/2012/174328. Epub 2012 Mar 26. PubMed PMID: 22550499; PubMed Central PMCID: PMC3329664.
• Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8. doi: 10.1002/cyto.b.21017. Epub 2012 Mar 29. PubMed PMID: 22467604.
• Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. doi: 10.1182/blood-2011-11-393264. Epub 2012 Feb 28. PubMed PMID: 22374701.

Publications

2013

• Jain R, T L, Chandran J, Jayandharan GR, Palle A, Moses PD. A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans. Blood Coagul Fibrinolysis. 2013; 24:890-2
• Devi GS, Arora N, Rajkumar SV, Edison ES, Srivastava A, Jayandharan GR*. Fluorescent PCR-based gene dose analysis for detection of deletion mutations in carriers of haemophilia. Haemophilia. 2013 Jul 16. doi: 10.1111/hae.12233.
• Sangeetha H, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR*. Adeno-associated virus (AAV) vectors in gene therapy: Immune challenges and strategies to circumvent them. Rev Med Virol; 2013, in press.
• Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep; 2013, 3: 1832. DOI: 10.1038/srep01832.
• Song L, Kauss MA, Kopin E, Chandra M, Ul-Hasan T, Miller E, Jayandharan GR,Rivers AE, Aslanidi GV, Ling C, Li B, Ma W, Li X, Andino LA, Zhong L, Tarantal AF, Yoder MC, Wong KK, Jr, Tan M, Chatterjee S, Srivastava A. Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo. Cytotherapy 2013, in press.
• Sumitha E, Jayandharan GR, Neeraj A, David S, Sankari Devi G, ShenbagaPriya P, Nair SC, George B, Viswabandya A, Mathews V, Chandy M, Srivastava A. Molecular basis of fibrinogen deficiency in 25 patients from India. Haemophilia2013, in press.
• Sen D, Gadkari RA, Sudha G, Gabriel N, Sathish Kumar Y, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC,Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus (AAV) serotype -8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods 2013; in press.
• Gabriel N, Hareendran S, Sen D, Gadkari RA, Govindarajan S, Hussain M, Duraiswamy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bio-Engineering of Adeno-Associated Virus Serotype (AAV)-2 Capsid at Serine/Threonine/Lysine Residues Improves Its Transduction Efficiency Both In Vitro and In Vivo. Hum Gene Ther Methods 2013; in press.
• Balakrishnan B, Sen D, David S, Srivastava A, Srivastava A, Jayandharan GR. Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus Vectors. PLoS ONE 2013; 8(1): e53845. doi:10.1371/journal.pone.0053845.
• Sen D, Chapla A, Walter N, Daniel V, Srivastava A, Jayandharan GR. Nuclear Factor (NF)-κB is a major regulator of blood induced joint damage in a murine model of hemophilia. J Thromb Haemost 2013, 11: 293-306.
• Song L, Li X, Jayandharan GR, Wang Y, Aslanidi GV, Ling C, Zhong L, Gao G, Yoder MC, Ling C, Tan M, Srivastava A. High-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivo. PLoS ONE 2013; in press.

2012

• Nair SC, Viswabandya A, Srivastava A Diagnosis and management of von Willebrand disease: a developing country perspective Semin Thromb Hemost. 2011 Jul;37(5):587-94. Epub 2011 Nov 18. Review.
• Mathews V, Chendamarai E, George B, Viswabandya A, Srivastava A Treatment of acute promyelocytic leukemia with single-agent arsenic trioxide. Mediterr J Hematol Infect Dis. 2011;3(1):e2011056. Epub 2011 Nov 28
• Balasubramanian P, Chendamarai E, Markose P, Fletcher L, Branford S, George B, Mathews V, Chandy M, Srivastava A International reporting scale of BCR-ABL1 fusion transcript in chronic myeloid leukemia: first report from India Acta Haematol. 2012;127(3):135-42. Epub 2012 Jan 12
• Jayandharan GR, Srivastava A, Srivastava A. Application of molecular genetics in haemophilia: from diagnoses to therapy. Sem Thromb Haemost 2012; 38: 64-78.
• Goodeve AC, Perry DJ, Cumming T, Hill M, Jennings I, Kitchen S, Walker I, Gray E, Jayandharan G, Tuddenham E. Genetics of Haemostasis. Haemophilia 2012; 18: S4, 73-80.
• Aslanidi GV, Rivers AE, Ortiz L, Govindasamy L, Ling C, Jayandharan GR, Zolotukhin S, Agbandje-McKenna M, Srivastava A. High-efficiency transduction ofhuman monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine. 2012; 30: 3908-17.
• Sellathamby S, Lakshmi KM, Busson M, Viswabandya A, George B, Mathews V, Chandy M, Charron D, Krishnamoorthy R, Tamouza R, Srivastava A Polymorphisms in the Immunoregulatory Genes are Associated with Hematopoietic Recovery and Increased Susceptibility to Bacterial Infections in Patients with Thalassaemia Major Undergoing Matched Related Hematopoietic Stem Cell Transplantation Biol Blood Marrow Transplant. 2012 Jan 16. [Epub ahead of print]
• Abraham A, Varatharajan S, Abbas S, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia. Pharmacogenomics. 2012 Feb;13(3):269-82.
• Jayandharan GR, Srivastava A, Srivastava A Role of molecular genetics in hemophilia: from diagnosis to therapy Semin Thromb Hemost. 2012 Feb;38(1):64-78. Epub 2012 Feb 7
• Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. Epub 2012 Feb 28.
• Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country.. Cytometry B Clin Cytom. 2012 Mar 29. doi: 10.1002/cyto.b.21017. [Epub ahead of print]
• Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia.. Eur J Clin Pharmacol. 2012 May 5. [Epub ahead of print]
• Sabapathy V, Ravi S, Srivastava V, Srivastava A, Kumar S. Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity.. Stem Cells Int. 2012;2012:174328. Epub 2012 Mar 26.
• Mayuranathan T, Rayabaram J, Edison ES, Srivastava A, Shaji RV.  A novel deletion of β-globin promoter causing high HbA2 in Indian population.Haematologica. 2012 May 11.
• David S, Jayandharan GR, Abraham A, Rr J, Devi GS, Patkar N, Shaji RV, Nair SC, Viswabandya A, Ahmed R, George B, Mathews V, Chandy M, Srivastava A. Molecular basis of Wiskott-Aldrich syndrome in patients from India. Eur J Haematol. 2012 Jun 9. doi: 10.1111/j.1600-0609.2012.01818.x.
• Parihar M, Kumar JA, Sitaram U, Balasubramanian P, Abraham A, Viswabandya A, George B, Mathews V, Srivastava A, Srivastava VM Leuk Lymphoma. 2012 Jan;53(1):103-9. Epub 2011 Sep 2.
• Edison ES, Shaji RV, Chandy M, Srivastava A.  Interaction of hemoglobin E with other abnormal hemoglobins.  Acta Haematol. 2011;126(4):246-8. Epub 2011 Oct 4. No abstract available.
• Jayandharan GR, Srivastava A. Hemophilia: disease, diagnosis and management. J Genet Syndr Gene Ther; 2012. doi: 10.4172/2157-7412.S1-005.
• Zhong L, Jayandharan GR, Aslanidi G, Zolutukin S, Herzog RW, Srivastava A. Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia J Genet Syndr Gene Ther; 2012. doi: 10.4172/2157-7412.S1-008.
• David S, Jayandharan GR, Abraham A, Rr J, Devi GS, Patkar N, Shaji RV, Nair SC, Viswabandya A, Ahmed R, George B, Mathews V, Chandy M, Srivastava A. Molecular basis of Wiskott-Aldrich syndrome in patients from India. Eur J Haematol. 2012 doi: 10.1111/j.1600-0609.2012.01818.

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