Staff >> Faculty >> Dr. Poonkuzhali Balasubramanian

Dr. Poonkuzhali Balasubramanian, M.Sc, PhD

Professor (Non-Medical), Department of Hematology
Christian Medical College

“Will be updated Soon”

Research interests

Pharmacokinetics and pharmacogenetics of HSCT conditioning regimen; Pharmacogenetics of anticancer drugs; mechanisms of drug resistance in leukemia

Ongoing Research Projects

• Pharmacogenetics of cytarabine and Daunorubicin in acute myeloid leukemia, funded by DBT, India, part of “DBT Programme support”, 2009-2014, Principal Investigator.
• Mechanisms of Imatinib resistance in chronic myeloid leukemia- funded by DBT, India, part of “DBT Programme support”, 2009-2014, Principal Investigator.
• Evaluation of prognostic markers in patients with acute myeloid leukemia- funded by DBT, India, part of “DBT Programme support”, 2009-2014, Co- principal Investigator.
•  “Pharmacogenetics of cytarabine and Daunorubicin Resistance in the Leukemic Stem Cell Compartment in acute myeloid leukemia”- INSERM-ICMR, Jan 2011- December 2012; Principal Investigator.

Education and Training

Dr. Poonkuzhali Balasubramanian

Professor (Non-Medical), Department of Hematology
Christian Medical College
Vellore- 632004, Tamilnadu, INDIA.
Phone: +91 416 2283476
Fax : 91-416-2226449
e-mail : [email protected] 

Selected Peer reviewed Publications

• Markose P, Chendamarai E, Poonkuzhali B, Shaji R.V, Vivi M Srivastava, Vikram Mathews, Biju George, Auro Viswabandya, Alok Srivastava and Mammen Chandy. Spectrum of Bcr-Abl kinase domain mutations in patients with chronic myeloid leukemia from India with suspected resistance to imatinib- mutations are rare and have different distributions. Leukemia Lymphoma 2009 Dec;50(12):2092-5
• Deeken JF, Robey RW, Shukla S, Steadman K, Chakraborty A, Poonkuzhali B, Schuetz EG, Holbeck S, Ambudkar SV, Bates SE. Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol. 2009 Nov;76(5):946-56.
• Charles M. Rudin, Wanqing Liu, Apurva Desai, Theodore Karrison, Xuemin Jiang, Linda Janisch, Soma Das, Jacqueline Ramirez, Balasubramanian Poonkuzhali, Erin Schuetz, Donna Lee Fackenthal, Peixian Chen, Deborah K. Armstrong, Julie R. Brahmer, Gini F. Fleming, Everett E. Vokes, Michael A. Carducci, Mark J. Ratain. Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. J Clin Oncol 2008; Mar 1;26(7):1119-27.
• Partha Krishnamurthy, Matthias Schwab, Kazumasa Takenaka, Deepa Nachagari, Jessica Morgan, Mark Leslie, Weinan Du, Kelli Boyd, Meyling Cheok, Hiromitsu Nakauchi, Richard Kim, Balasubramanian Poonkuzhali, Erin Schuetz, William Evans, Mary Relling and John Schuetz. Transporter-Mediated Protection Against Thiopurine-Induced Hematologic Toxicity. Cancer Res 2008; 68(13):4983-9.
• Balasubramanian Poonkuzhali, Jatinder Lamba, Stephen Strom, Alex Sparreboom, Kenneth Thummel, Paul Watkins, and Erin Schuetz. Association of BCRP/ABCG2 Phenotypes with Novel promoter and intron1 SNPs. Drug Metab Dispos. 2008 Apr;36(4):780-95.
• Marzolini C, Tirona RG, Gervasini G, Poonkuzhali B, Assem M, Lee W, Leake BF, Schuetz JD, Schuetz EG, Kim RB. A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. Mol Endocrinol. 2007 Aug;21(8):1769-80.
• Chandy M, Balasubramanian P, Ramachandran SV, Mathews V, George B, Dennison D,Krishnamoorthy R, Srivastava A. Randomized trial of two different conditioning regimens for bone marrow transplantation in thalassemia--the role of busulfan pharmacokinetics in determining outcome. Bone Marrow Transplant. 2005 Nov;36(10):839-45.
• Srivastava A, Poonkuzhali B, Shaji RV, George B, Mathews V, Chandy M, Krishnamoorthy R. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
• Poonkuzhali B, Chandy M, Srivastava A, Dennison D, Krishnamoorthy R. Glutathione S-transferase activity influences busulfan pharmacokinetics innpatients with beta thalassemia major undergoing bone marrow transplantation. Drug Metab Dispos. 2001 Mar;29(3):264-7.
• Poonkuzhali B, Srivastava A, Quernin MH, Dennison D, Aigrain EJ, Kanagasabapathy AS, Krishnamoorthy R, Chandy M. Pharmacokinetics of oral busulphan in children with beta thalassaemia major undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant. 1999 Jul;24(1):5-11.
• http://www.ncbi.nlm.nih.gov/pubmed?term=poonkuzhali B
• http://www.ncbi.nlm.nih.gov/pubmed?term=Balasubramanian%20P%2C%20Vellore